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GuangZhou Herbal Recipe Biotechnology Co., Ltd
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Jintropin HGH, high quality low price, shipping warrantee 

Price: 6.0~8.5 USD 
Payment Terms: T/T,WU;MoneyGram 
Place of Origin: , China (Mainland) 
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Product Detail

Model No.: 10iu
Production Capacity: 100000 vails/month
Delivery Date: within 2 days
CAS No.: 9002-72-6
Means of Transport: Air
Packing: 10iu x 10 vials/ kit
Brand Name: Jintropin
Purity: 98%

pharmaceutical grade high quality, the purity is up to 98%. Factory supply directly, lowest price and shipping warrantee

JINTROPIN
Recombinant Human Growth Hormone for Injection
Please read the package insert carefully and administer under the guidance of physicians
JINTROPIN should not be used for growth promotion in children with closed epiphyses.
JINTROPIN should not be used in patients with severe generalized infections who are in acute shocks.
[NAME OF THE MEDICINAL PRODUCT]
Generic Name: Recombinant Human Growth Hormone for Injection
Trade Name: JINTROPIN
[INGREDIENTS]
Recombinant human growth hormone and excipients.
Molecular Formula: C990H1528N262O300S7, with 191 amino acid residues.
Molecular weight : 22125D
Origin of the Active Ingredient: JINTROPIN is a recombinant human growth hormone (rhGH) produced by gene recombination E. Coli secretion expression technology. Its precursor synthesized in E. Coli including gene of human growth hormone(hGH) was secreted to periplasmic space of the cell guided under signal peptide. The signal peptide was removed and polypeptide molecule is folded exactly to growth hormone (GH) molecule. JINTROPIN has 191 amino acid residues and a molecular weight of 22125 daltons. It's amino acid content, structure and sequence are identical to those of hGH.
[CHARACTERS]
White lyophilized powder
[INDICATIONS]
Pediatric growth retardation due to inadequate secretion of endogenous Gh.
Severe burns.
Growth hormone deficiency (GHD) due to diseases of hypothalamus—pituitary gland . or as diagnosed by 2 independent GH stimulation tests.
[STRENGTHS]
2.5IU/0.85mg/1.0ml/vial
4.0IU/1.33mg/1.0ml/ vial
4.5IU/1.7mg/1.0ml/ vial
10IU/3.7mg/10.0ml/ vial
12IU/4.0mg/1.0ml/ vial
[DOSAGE AND ADMINISTRATION]
-Before administration, add 1 ml of WFI to the rhGH vial of lyophilized powder. And make the solvent run slowly down the side of the vial. Swirl the vial with a gentle rotary motion until contents are dissolved completely. Do not shake vigorously.
-The dose of administration should be individual for each patient. For growth –promotion purpose in children, the recommended dose is 0.1-0.15IU/kg Alay. Once per day, subcutaneous injection. The period of treatment is from 3 months to 3 years. Or follow your physicians prescription.
For severe burn patients, a daily dose of 0.2-0.4IU/kg subcutaneous injections is recommended. The period of treatment is about 2 weeks.
The dose night require adjustment individually for human replacement therapy. Generally the dose is from small dose, e.g. 0.5IU(0.17mg)/day or up to 0.02IU/kg /day, it is equal to 0.007mg/kg/day. After 1-2 months treatment, the dose might be modulated gradually to 0.04IU/kg/day, it is equal to 0.013mg/kg/day. The daily dose should be modulated according to the determination of Insulin-like Growth Factor-I(IGF-I) in serum. The dose may decrease with age increasing.
[ADVERSE REACTIONS]
JINTROPIN may cause temporary hyperglycemia, which will usually return to normal after continual uses, or stop using.
In clinical trials in children with short stature, side effects have been noted in approximately 1% of the subjects, The most common effects are temporary local response at injection sites(such as pain, numbness, redness and swelling and etc.) and symptoms of fluid retention (such as periphery oedema, arthralgia and myosalgia). These side effects have an early onset after initiation of therapy, but with a reduction in incidence and prevalence over time which rarely influence daily activities.
During long-term JINTROPIN treatment a few patients may develop antibodies to the protein. The affinity of the antibody is usually low, and it has no exact clinical significance, However , if the expected growth effect is not observed There is a possibility that formation of antibody taking place in the body. If the affinity exceeds 2mg/L. It might interfere with the treatment.
[CONTRAINDICATIONS]
JINTROPIN should not be used for growth promotion in children with closed epiphyses.
JINTROPIN should not be used in patients with severs generalized infections who are in acute shocks.
[WARNINGS AND PRECAUTIONS]
Diagnosis confirmation is required before initiation of the treatment, Therapy with JINTROPIN should be prescribed directly by qualified physicians.
In diabetes mellitus patients, the dose of insulin might require adjustment by physicians before JINTROPIN treatment.
Simultaneous glucocorticoid therapy will inhibit the growth –promoting effect of JINTROPIN. Patients with ACTH deficiency should have their glucocorticoid-replacement dose carefully adjusted to avoid an inhibitory effect on growth(see DRUGINTERACTIONS).
Hypothyroidism may develop during JINTROPIN therapy in very few patients, which should be corrected promptly to avoid the compromised curative effect of JNTROPIN. Therefore, Thyroid function should be monitored periodically during JNTROPIN administration, and , thyroid hormone replacement should be initiated if necessary.
Slipped capital femoral epiphysis may occur in patients with endocrine disorders(including GHD). Evaluation should be made carefully if limp emerges during JINTROPIN treatment.
Sometimes JINTROPIN may reduce insulin sensitivity. Patients should be monitored closely for evidence of glucose intolerance.
Insulin treatment might be needed if BG exceeds 10mmol/L during treatment, If BG cannot be controlled with a dose of insulin exceeding 150IU/day. Stop JINTROPIN treatment.
The injection site should be varied to prevent lipoatrophy.
Athletes should administer with caution.
[MEDICATION FOR WOMEN IN PREGNANCY AND LACTATION]
It should not be used for women in pregnancy and lactation.
[MEDICATION FOR CHILDREN]
There is no significant difference in JINTROPIN's pharmacology and pharmacokinetics between children and adults. Administer JINTROPIN safely according to weights.
[MEDICATION FOR ELDERS]
There is no clinical report in senior population.
[DRUG INTERACTIONS]
Simultaneous glucocorticoid therapy might inhibit the effect of hGH . Generally, the dose of glucocorticoid can not exceed 10-15mg CORT/m²of surface areas. Growth rate can be increased by the combination with other non-androgen steroids.
[OVERDOSE]
There is no report on acute overdose. Overdose could lea to initially hypoglycemia and subsequently hyperglycemia. Long-term overdose could result in symptoms of acromegaly, consistent with the known effects of excessive GH.
[PHARMACOLOGY]
HGH was secreted by anterior lob of the pituitary, It is a peptide hormone with 191 amino acids, JINTROPIN is a rhGH produced by recombinant DNA technology in E.coli with secretion expression. The content and sequence of JINTROPIN are completely identical with those of Hgh JINTROPIN is synthesized in e. coli as a prehormone. The prehormone is composed of GH with a signal peptide derived originally from the bacterium. The prehormone splits in the cytosol of bacterium, and then the finished product, similar to the native GH, is released to periplasmic space, The product is then collected though lysis of the outer menbrane, which leaves inner membrane intact, and thus guarantees almost no contamination from other bacteria proteins.
The effect of the secretion expression rhGH is the same as that of the endogenous GH in human body, JINTROPIN stimulates cartilage cells of osteoepiphysis to differentiate and propagate; it stimulates stroma cells of the cartilage to grow; it stimulates osteoblast to differentiate and regenerate; it causes acceleration of linear growth and ossature widening, JINTROPIN promotes whole-body synthesis of proteins; it corrects the condition of negative nitrogen balance after operation and other wounds; it corrects hypoproteinemia initiated by severe infections and hepatic cirrhosis. JINTROPIN stimulates the synthesis of immune globulin; it stimulates the generation of lymphoid tissue, macrophage and homeocyte; it increases the ability of anti-infection, JINTROPIN stimulates the synthesis from collagen cells to fibrocytes in burn wounding and operative incisions, it stimulates differentiation and generation of macrophage; it accelerates wound healing. JINTROPIN promotes the synthesis of protein; of cardiac muscle; it increase the contraction force of cardiac muscle; it decrease myocardial consumption of oxygen; it regulates fat metabolism; it decrease levels of cholesterol and low density lipoprotein in serum. JINTROPIN complements the insufficient and deficiency of GH, it adjusts fat metabolism, bone metabolism, cardiac and renal function.
[PHARMACOKINETICS]
It has been reported in literature that the therapeutic effects are the same for both subcutaneously and intramuscularly administrations. Usually subcutaneously administration cause higher concen